![]() E) En face OCTA of the SCP centered on the macula, shows extensive capillary nonperfusion that’s better appreciated here than on the FA. There are widespread leaking microaneurysms. D) FA of another patient with diabetic retinopathy during the late phase also shows an enlarged FAZ (yellow circle), as well as large areas of nonperfusion. C) En face OCTA of the deep capillary plexus (DCP), shows the extension of the capillary closure in the deep plexus, which can’t be appreciated on the FA. B) En face optical coherence tomography angiogram of the superficial capillary plexus (SCP), highlights the extent of the FAZ enlargement, as well as the areas of capillary nonperfusion. Notice the obscuration of the edges of the FAZ by the leakage. There are also areas of hyperfluorescence caused by leaking microaneurysms, as well as fluorescence blocked by intraretinal hemorrhage. A) Fluorescein angiogram of a patient with diabetic retinopathy during the late phase shows an enlarged foveal avascular zone (yellow circle). Here, we’ll look at the pros and cons of both approaches.įigure 1. Therefore, the important question of whether OCTA can completely replace conventional dye-based angiography in modern day clinical practice remains unanswered. OCTA, however, still has several limitations of its own. 6,7 These limitations spurred the development of faster, safer imaging tools, capable of effectively imaging both the retinal and choroidal circulations, as represented by optical coherence tomography angiography. 5 Moreover, FA is only a two-dimensional study focusing on the superficial retinal circulation, without the ability to visualize the deeper capillary structures, and ICGA is mostly useful for imaging the choroid. 1-4 Despite their widespread success, fluorescein and indocyanine green angiography are invasive and time-consuming, in addition to having the potential for allergic reactions to the dyes. F or decades, dye-based angiography has been the gold standard clinical imaging modality for evaluating retinal and choroidal vascular pathologies. ![]()
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